Product Name: Poloxamer

Synonyms: Polyethylene-polypropylene glycol；

Molecular Formula: HO.(C2H4O)m.(C3H6O)n.H

Molecular Weight: 102.1317

CAS No.: 9003-11-6

EINECS: 618-355-0

Description

Poloxamer is a new type of polymer non-ionic surfactant, which is a block copolymer of polyoxyethylene and polyoxypropylene ether. It can also be used as emulsifier and stabilizer.

Benefits

1. As emulsifier and stabilizer: poloxamer188 (Pluronic F68), as an oil in water emulsifier, is one of the few synthetic emulsifiers used in intravenous emulsion. It has stable physical properties and can withstand hot pressure sterilization and low temperature freezing.

2. As a solubilizer: This product can form micelles due to surfactants and increase the surface solubility of various drugs,

3. As absorption enhancer: on the one hand, because this product slows the intestinal peristalsis, the retention time of the drug in the gastrointestinal tract increases and the absorption increases, which can improve the bioavailability of oral preparations. On the other hand, this product has good compatibility with the skin, increases the skin permeability and promotes the absorption of external agents.

4. As a slow release material: a large molecular weight solid product, used as binder, coating material, etc. to prepare tablets, capsules, gels, etc., to achieve sustained release and controlled release purposes.