Description

The hydrophobic part of licorice extract contains a variety of flavonoids. Glabridin, as the main component of its hydrophobic part, has an inhibitory effect on melanin production, and also has anti-inflammatory and anti-oxidant properties.

Benefits

1. Glabridin Inhibits Melanin Synthesis

The main whitening mechanism of Glabridin powder is to competitively inhibit tyrosinase activity, taking part of the tyrosinase away from the catalytic loop of melanin synthesis, preventing the binding of the substrate and tyrosinase, thereby inhibiting melanin synthesis.

2. Glabridin for Anti-oxidation

Glabridin powder itself has a good antioxidant effect. Experiments have shown that it has the ability to scavenge oxygen free radicals similar to superoxide dismutase (SOD). Glabridin powder can not only inhibit the activity of tyrosinase, but also inhibit dopachrome inter-conversion and dihydroxyindole carboxylic acid oxidase activity.

3. Glabridin for Anti-inflammation

Water-soluble Glabridin powder can be used to improve bioavailability, and has less cytotoxicity. Also, it has a better melanin inhibitory effect, as well as effectively reduces the expression of inflammatory cytokines, interleukin-6 and interleukin-10. The in vitro anti-inflammatory effect of Glabridin powder is also manifested in the inhibition of superoxide anion production and cyclooxygenase activity. Therefore, it can be used as a topical therapeutic agent to inhibit skin inflammation and combat skin damage caused by ultraviolet radiation.