Product Name: D-Cycloserine

Synonyms: D-4-Amino-3-isoxazolidinone

Molecular Formula: C3H6N2O2

Molecular Weight: 102.09

CAS No.: 68-41-7

EINECS: 200-688-4

Description

D-Cycloserine is an antibiotic which is used in the treatment of tuberculosis. Under mildly acidic conditions, cycloserine hydrolyzes to give hydroxylamine and D-Serine. Cycloserine can be thought of a cyclized version of serine, with an oxidative loss of dihydrogen to form the nitrogen-oxygen bond. Cycloserine is stable under basic conditions, with the greatest stability at pH=11.5.

Benefits

Cycloserine works as an antibiotic by inhibiting cell-wall biosynthesis in bacteria. As a cyclic analogue of D-alanine, cycloserine acts against two crucial enzymes important in the cytosolic stages of peptidoglycan synthesis: alanine racemase (Alr) and D-alanine: D-alanine ligase (Ddl). This effectively leads to inhibition of peptidoglycan synthesis.