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N-Acetyl-L-Tyrosine
Product details

N-Acetyl-L-tyrosine [537-55-3]

Name

N-Acetyl-L-tyrosine

Molecular Formula

C11H13NO4

Molecular Weight

223.23

CAS Registry Number

537-55-3

EINECS

208-671-3

Melting point

149-152 ºC

alpha

47.5 º (c=2, water)

 

What Is N-Acetyl L-Tyrosine?

N-Acetyl L-Tyrosine, or NALT for short, is considered to be a modified formulation of the non-essential amino acid, L-Tyrosine.

L-Tyrosine is an amino acid that the body is capable of producing internally, but supplementation is often necessary to optimize cognitive function.

NALT is modified from normal Tyrosine because it contains the addition of acetic acid. This is believed to help increase the compound’s bioavailability so that it is better absorbed directly into the bloodstream, however research on this is limited.

Acetic acid also has some important benefits in its own right for brain health. For these reasons, N-Acetyl L-Tyrosine is a popular form of supplemental L-Tyrosine.

Amino acids are vital to the body for a number of reasons. They help to make proteins, build up new cells, aid in the recovery and rebuilding of muscles, etc. But one of the main things which makes Tyrosine special is that it also is a precursor to the catecholamines.

Catecholamines are a group of monoamine compounds that act as hormones and neurotransmitters in the body. The main catecholamines are Dopamine, Epinephrine (Adrenaline), and Norepinephrine (Noradrenaline). These powerful neurotransmitters are associated with mood, attention, focus, and alertness.

 

Benefits of N-Acetyl-L-Tyrosine

The primary benefits of N-acetyl-L-tyrosine revolve around dopamine and adrenaline metabolism. Studies suggest that NALT can increase mood in military personnel exposed to stressors like cold and altitude . One can reasonably assume this mood boost is via dopamine improvements from taking the L-tyrosine.

Another benefit of NALT is for memory protection against stress. One study showed that L-tyrosine could increase adrenaline concentrations and reverse memory loss caused by stress. In fact, one of the primary benefits of N-acetyl-L-tyrosine is related to handling stress as much of the literature suggests.

 

Under stressful conditions (acute stress rather than chronic) general cognitive enhancement suffers greatly. Most of the studies with L-tyrosine (and relate to NALT) are on military personnel tested in stressful situations. One study on cadets showed cognitive preservation during a week of difficult training [8]. Another measured how L-tyrosine improved mental performance during extreme sleep deprivation as well.

The benefit of using NALT is that the substance has increased solubility. In fact, it is 20 times more water soluble than L-tyrosine alone and anecdotal effects suggest improved mood and focus even though there isn’t much evidence to support those claims.