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L-Pyroglutamic Acid
Product details

L-Pyroglutamic acid [98-79-3]


L-Pyroglutamic acid


5-Oxoproline; 5-Oxopyrrolidine-2-carboxylic acid; L-5-Pyrrolidone-2-carboxylic acid; (S)-(-)-2-Pyrrolidone-5-carboxylic acid

Molecular Formula


Molecular Weight


CAS Registry Number




Melting point

152-162 ºC


-27.5 º (c=10, 1 N NaOH)

Water solubility

10-15 g/100 mL (20 ºC)



L-pyroglutamic acid is an amino acid which is prevalent in all living organisms. It is not an essential amino acid, as it can be produced endogenously in humans, usually from L-proline or L-glutamate as a dietary source. L-pyroglutamic acid bears the same 2-pyrrolidinone skeletal structure common to drugs of the racetam family, and is structurally related to fasoracetam, which itself is an amide of pyroglutamic acid (L-pyroglutamic acid N,N-piperidide, specifically).

This compound is not for human consumption, and its sale is strictly intended for research purposes only.

Available as the free zwitterion.




1. As an antioxidant in cosmetics, it works synergistically with phenolic derivatives to prevent skin aging.

Such as moisturizing effect; whitening effect; softening effect; transparent effect;

2. As a food additive and pharmaceutical intermediate

3. Physical supplements such as anti-fatigue effects


L-Pyroglutamic acid Background and Benefits

Pyroglutamic acid is a derivative of the amino acids glutamine and glutamic acid. It also known by other names such as pyroglutamate, 5-oxoproline and pidolic acid.

Pyroglutamic acid is a nonessential nutrient, meaning that the body normally biosynthesizes adequate quantities of pyroglutamic acid. It is typically formed in the body as a by-product of the glutathione cycle, in which the enzyme 5-oxoprolinase acts upon glutamic acid. Some pyroglutamic acid also forms when glutamine or glutamic acid spontaneously cyclizes. Pyroglutamic acid is available from a variety of dietary sources, including fruits and vegetables. Bacteriorhodopsin is one of the many proteins that contain pyroglutamic acid as a component.


Pyroglutamic acid has two specific forms known as enantiomers. These include D-pyroglutamic acid and L-pyroglutamic acid, with L-pyroglutamic acid being the biologically active enantiomer in humans. The primary biochemical use of L-pyroglutamic acid is believed to be increasing the activity of the neurotransmitter acetylcholine. It may also be used in the production of the neurotransmitters gamma-aminobutyric acid (GABA) and glycine.


Acetylcholine acts on both the central nervous system and peripheral nervous system. It is also the only neurotransmitter that affects the motor portion of the somatic nervous system. Furthermore, acetylcholine is the primary neurotransmitter for the autonomic ganglia.