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Alpha-Ketoglutaric Acid
Product details

2-Ketoglutaric acid [328-50-7]


2-Ketoglutaric acid


2-Oxoglutaric acid; 2-Oxopentanedioic acid ; alpha-Ketoglutaric acid

Molecular Formula


Molecular Weight


CAS Registry Number




Melting point

113-115 ºC



Alpha-ketoglutaric acid is a substance found naturally in the human body. Also available in dietary supplement form, alpha-ketoglutaric acid plays a key role in the Krebs cycle (a series of chemical reactions involved in the body's production of energy). Alpha-ketoglutaric acid supplements are purported to offer a variety of health benefits.

Alpha-ketoglutaric acid also occurs in salt form, as a substance called alpha-ketoglutarate. Alpha-ketoglutarate is involved in the formation of glutamine, an amino acid required for protein synthesis and for proper functioning of the immune system.



Alpha-ketoglutaric acid is often said to enhance athletic performance. Some alternative medicine proponents claim that use of alpha-ketoglutaric acid can help stimulate the body's production of protein, stabilize blood sugar levels during exercise, and improve exercise endurance.

In alternative medicine, alpha-ketoglutaric acid is also said to help with the following health problems:

bacterial infections


kidney disease

yeast infections



Although research on the health effects of alpha-ketoglutaric acid is very limited, some preliminary research suggests that alpha-ketoglutarate may offer certain health benefits. Here's a look at several key findings from the available studies:

1) Hemodialysis

Alpha-ketoglutarate may be of some benefit to people undergoing hemodialysis. It helps boost amino acid metabolism and decrease hyperphosphatemia (a condition marked by abnormally elevated levels of phosphate in the blood).


2) Cardiac Surgery

Alpha-ketoglutarate may help improve kidney function among patients undergoing cardiac surgery, Study results suggest that alpha-ketoglutarate may enhance blood flow in the kidneys.


3) Longevity

Alpha-ketoglutarate interfered with cellular energy production and mimicked the effects of diets very low in calories, which have been shown to extend the lifespan of certain animals. According to the study's authors, alpha-ketoglutarate boosted the lifespan of the treated worms by approximately 50% over untreated controls.